Name SUGIYAMA Hiroyuki
Year of birth 1944

Current appointment

(position and institution)

Professor, Department of Biology, Faculty of Sciences, Kyushu University
Address 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan
Phone +81-(0)92-642-2630
Fax +81-(0)92-642-2645
E-mail hsugiscb@mbox.nc.kyushu-u.ac.jp
URL http://www.biology.kyushu-u.ac.jp/~biophys/bukka.html
Fields of general research Neuroscience
Fields of specialization Molecular mechanisms of synaptic plasticity

Subject of research work
and/or
titles of lecture and
discussion

Molecular Neurobiology

Research reports (papers
and
reviews) within recent
5 years

- Ito, I., Akashi, K., Sakimura, K., Mishina, M. and Sugiyama, H.: Distribution and development of NMDA receptor activities at hippocampal synapses examined using mice lacking the e1 subuint gene, Neurosci.Res., 30, 119-123 (1998).

- Kasahara, J. and Sugiyama, H.: Modulation of glutamate sensitivities by inhibitors of a protein kinase and a protein phosphatase in cultured rat Purkinje cells, Neurosci.Lett., 247, 139-142 (1998).

- Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H. and Inokuchi, K.: Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors, J.Biol.Chem., 273, 23969-23975 (1998).

- Osaki, T., Omotezako, M., Nagayama, R., Hirata, M., Iwanaga, S., Kasahara, J., Hattori, J., Ito, I., Sugiyama, H. and Kawabata, S.: Horseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neruotoxins, J.Biol.Chem., 274, 26172-26178 (1999).

- Ito, I., Kawakami, R., Sakimura, K., Mishina, M. and Sugiyama, H.: Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses, Neuropharmacology, 39, 943-951 (2000).

- Minakami, R., Kato, A. and Sugiyama, H.: Interaction of Vesl-1L/Homer 1c with syntaxin 13, Biochem.Biophys.Res.Commun., 272, 466-471 (2000).

- Kato, A., Fukuda, T., Fukazawa, Y., Isojima, Y., Fujitani, K., Inokuchi, K. and Sugiyama, H.: Phorbol esters promote postsynaptic accumulation of Vesl-1S/Homer-1a protein, Europ.J.Neurosci., 13, 1292-1302 (2001).

- Ageta, H., Kato, A., Hatakeyama, S., Nakayama, K., Isojima, Y. and Sugiyama, H.: Regulation of the level of Vesl-1S/Homer-1a proteins by ubiquitin-proteasome proteolytic systems, J.Biol.Chem., 276, 15893-15897 (2001).

- Coutinho, V., Kavanagh, I., Sugiyama, H., Tones, M.A. and Henley, J.M.: Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1c, Mol.Cell.Neurosci., 18, 296-306 (2001).

- Morioka, R., Kato, A., Fueta, Y. and Sugiyama, H.: Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse, Neurosci.Lett., 313, 99-101 (2001).

- Ageta, H., Kato, A., Fukazawa, Y., Inokuchi, K. and Sugiyama, H.: Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins, Mol.Brain Res., 97, 186-189 (2001).

- Matsushima, N., Hirose, S., Iwata, H., Fukuma, G., Yonetani, M., Nagayama, C., Hamanaka, W., Matsunaka, Y., Ito, M., Kaneko, S., Mitsudome, A. and Sugiyama, H.: Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor alpha4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in ooxytes, Epilepsy Res., 48, 181-186 (2002).

Research theme of doctor
course
students in your
laboratory

Synapse-specific regulation of subunit composition of NMDA receptors in the rodent hippocampus.
Characterization of proteins specifically interacting with postsynaptic Homer/Vesl family proteins.

French researchers you

collaborate with

Currently None